Publications

[2016]

Brown, K., J. Selfridge, S. Lagger, J. Connelly, D. De Sousa, A. Kerr, S. Webb, J. Guy, C. Merusi, M. V. Koerner and A. Bird (2015). The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome. Hum Mol Genet. 3: 558-570.

Katz, D. M., A. Bird, M. Coenraads, S. J. Gray, D. U. Menon, B. D. Philpot and D. C. Tarquinio (2016). Rett Syndrome: Crossing the Threshold to Clinical Translation. Trends Neurosci 39(2): 100-113.

[2015]

Lyst, M. J. and A. Bird (2015). Rett syndrome: a complex disorder with simple roots. Nat Rev Genet 16(5): 261-275.

Cook, P. C., H. Owen, A. M. Deaton, J. G. Borger, S. L. Brown, T. Clouaire, G. R. Jones, L. H. Jones, R. J. Lundie, A. K. Marley, V. L. Morrison, A. T. Phythian-Adams, E. Wachter, L. M. Webb, T. E. Sutherland, G. D. Thomas, J. R. Grainger, J. Selfridge, A. N. McKenzie, J. E. Allen, S. C. Fagerholm, R. M. Maizels, A. C. Ivens, A. Bird and A. S. MacDonald (2015). A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nat Commun 6: 6920.

Illingworth, R.S., Gruenewald-Schneider, U., De Sousa, D., Webb, S., Merusi, C., Kerr, A.R., James, K.D., Smith, C., Walker, R., Andrews, R., and Bird, A.P. (2015). Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome. Nucleic acids research 10.1093/nar/gku1305.

PubMed abstract  pdf

[2014]

Song, C.D., Feodorova, Y., Guy, J., Peichl, L., Jost, K.L., Kimura, H., Cardoso, M.C., Bird, A., Leonhardt, H., Joffe, B., et al. (2014). DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution. Epigenetics & chromatin 7. doi; 10.1186/1756-8935-7-17

PubMed abstract  pdf

Bassett, A.R., Akhtar, A., Barlow, D.P., Bird, A.P., Brockdorff, N., Duboule, D., Ephrussi, A., Ferguson-Smith, A.C., Gingeras, T.R., Haerty, W., et al. (2014). Considerations when investigating lncRNA function in vivo. eLife 3, e03058.

PubMed abstract 

Clouaire T, Webb S, Bird A. Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells. Genome Biol. 2014 Sep 4;15(9):451.
PubMed abstract  pdf 

Wachter E, Quante T, Merusi C, Arczewska A, Stewart F, Webb S, Bird A. Synthetic CpG islands reveal DNA sequence determinants of chromatin structure. Elife. 2014 Sep 26;3. doi: 10.7554/eLife.03397.
PubMed abstract  pdf

Deaton AM, Cook PC, De Sousa D, Phythian-Adams AT, Bird A, Macdonald AS.(2014). A unique DNA methylation signature defines a population of IFN-γ/IL-4 double-positive T cells during helminth infection. Eur J Immunol. 2014 Feb 27.
PubMed abstract  pdf

[2013]

McLeod, F., Ganley, R., Williams, L., Selfridge, J., Bird, A. and Cobb, S.R. (2013). Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome. Neuroscience 231, 195-205.
PubMed Abstract  pdf

Garg SK, Lioy DT, Cheval H, McGann JC, Bissonnette JM, Murtha MJ, Foust KD, Kaspar BK, Bird A, Mandel G. Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome. J Neurosci. 2013 Aug 21;33(34):13612-13620.
PubMed Abstract  pdf

Ebert DH, Gabel HW, Robinson ND, Kastan NR, Hu LS, Cohen S, Navarro AJ, Lyst MJ, Ekiert R, Bird AP, Greenberg ME.(2013).Activity-dependent phosphorylation of MECP2 threonine 308 regulates interaction with NcoR. Nature. 2013 Jun 16.
PubMed Abstract  pdf

Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J, Selfridge J, Guy J, Kastan NR, Robinson ND, de Lima Alves F, Rappsilber J, Greenberg ME, Bird A. (2013). Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.Nat Neurosci. 16(7):898-902.
PubMed Abstract  pdf

Bird, A. (2013). Instant Expert 29: Epigenetics. New Scientist No2898, i-viii.

[2012]

Clouaire T, Webb S, Skene P, Illingworth R, Kerr A, Andrews R, Lee JH, Skalnik D, Bird A.(2012).  Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells.  Genes Dev.26(15):1714-28
PubMed Abstract  pdf

Cheval, H., Guy, J., Merusi, C., De Sousa, D., Selfridge, J., and Bird, A. (2012). Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows. Hum Mol Genet. PMID: 22653753
PubMed Abstract  pdf

Yazdani, M., Deogracias, R., Guy, J., Poot, R.A., Bird, A. and Barde, Y.A. (2012). Disease Modeling Using Embryonic Stem Cells: MeCP2 Regulates Nuclear Size and RNA Synthesis in Neurons. Stem Cells. 2012 Oct;30(10):2128-39.
PubMed Abstract  pdf

Robinson L, Guy J, McKay L, Brockett E, Spike RC, Selfridge J, De Sousa D, Merusi C, Riedel G, Bird A, Cobb SR. Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome. Brain. 2012 Sep;135
PubMed Abstract  pdf

[2011]

Jacky Guy, Hélène Cheval, Jim Selfridge, and Adrian Bird. The Role of MeCP2 in the Brain. Annual Review of Cell and Developmental Biology. Vol. 27: 631-652.
PubMed Abstract  pdf

Deaton AM, Bird A.(2011). CpG islands and the regulation of transcription. Genes Dev. 25(10):1010-22.
PubMed Abstract  pdf

Deaton AM, Webb S, Kerr AR, Illingworth RS, Guy J, Andrews R, Bird. Cell type-specific DNA methylation at intragenic CpG islands in the immune system. A. Genome Res. 2011 Jul;21(7):1074-86.
PubMed Abstract  pdf

Cortazar, D., Kunz, C., Selfridge, J., Lettieri, T., Saito, Y., MacDougall, E., Wirz, A., Schuermann, D., Jacobs, A.L., Siegrist, F., 
Steinacher, R., Jiricny, J., Bird, A. and Schar, P. (2011). Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature 470, 419-423.
PubMed Abstract  pdf

Bird, A. (2011). Putting the DNA back into DNA methylation. Nat Genet 43, 1050-1051.

Bird, A. (2011). The Dinucleotide CG as a Genomic Signalling Module. J Mol Biol 409, 47-53.
PubMed Abstract  pdf

[2010]

Illingworth RS, Gruenewald-Schneider U, Webb S, Kerr AR, James KD, Turner DJ, Smith C, Harrison DJ, Andrews R, Bird AP. (2010). Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet. 6(9). pii: e1001134.
PubMed Abstract  pdf

Thomson JP, Skene PJ, Selfridge J, Clouaire T, Guy J, Webb S, Kerr AR, Deaton A, Andrews R, James KD, Turner DJ, Illingworth R, Bird A. (2010). CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature. 464(7291):1082-6.
PubMed Abstract  pdf

Athanasiadou, R., de Sousa, D., Myant, K., Merusi, C., Stancheva, C. and Bird, A. (2010). Targeting of de novo DNA methylation throughout the Oct4 gene regulatory region in differentiating embryonic stem cells. PloS one 5, e9937.
PubMed Abstract  pdf

Skene PJ, Illingworth RS, Webb S, Kerr AR, James KD, Turner DJ, Andrews R, Bird AP.(2010). Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Mol Cell.26;37(4):457-68 .
PubMed Abstract  pdf

Cobb, S., Guy, J. & Bird, A. (2010). Reversibility of functional deficits in experimental models of Rett syndrome. Biochem Soc Trans. 38, 498-506 .
PubMed Abstract 

[2009]

Schmiedeberg, L., Skene, P., Deaton, A., Bird, A.(2009). A temporal threshold for formaldehyde crosslinking and fixation.PLoS One 2009;4(2):e4636
PubMed Abstract  pdf

Illingworth RS, Bird AP. (2009). CpG islands - 'A rough guide'. FEBS Lett. 2009 Apr 17.
PubMed Abstract  pdf

[2008]

Bird, A. (2008). The methyl-CpG-binding protein MeCP2 and neurological disease. Biochem Soc Trans. 2008 Aug;36(Pt 4):575-83.
PubMed Abstract 

Illingworth, R., Kerr, A., Desousa, D., Jørgensen, H., Ellis, P., Stalker, J., Jackson, D,, Clee, C,, Plumb, R., Rogers, J,, Humphray, S., Cox, T., Langford, C., Bird, A. (2008). A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol. 6(1):e22.
PubMed Abstract  pdf

Martin V, Jørgensen HF, Chaubert AS, Berger J, Barr H, Shaw P, Bird A, Chaubert P. (2008). MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells. Pathobiology. 75(5):281-7.
PubMed Abstract  pdf

Ho, K.L., McNae, I.W., Schmiedeberg L., Klose, R.J., Bird, A.P., Walkinshaw, M.D.(2008). MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell. 29:525-31
PubMed Abstract  pdf

Suzuki, M.M. and Bird, A. (2007). DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet. 9(6):465-76.
PubMed Abstract  pdf

Bird, A. The methyl-CpG-binding protein MeCP2 and neurological disease. (2008).Biochem Soc Trans. 36, 575-83.
PubMed Abstract 

[2007]

Li, E. & Bird, A. DNA methylation in mammals. (2007) "Epigenetics" Editors: Allis, C. D., Jenuwein, T., Reinberg, D. Cold Spring Harbor Press., 341 - 355

Bird, A. (2007). Perceptions of epigenetics. Nature. 447:396-8.

Bird, A. Q & A: Adrian Bird. Current Biology (2007)

Suzuki, M.M., Kerr, A.R., De Sousa, D., Bird, A. (2007). CpG methylation is targeted to transcription units in an invertebrate genome. Genome Res. 17(5):625-31.
PubMed Abstract  pdf

Nan X, Hou J, Maclean A, Nasir J, Lafuente MJ, Shu X, Kriaucionis S, Bird A. (2007). Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc Natl Acad Sci U S A. 104(8):2709-14.
PubMed Abstract  pdf

Berger, J., Sansom, O., Clarke, A., Bird, A. (2007). MBD2 is required for correct spatial gene expression in the gut. Mol Cell Biol. 11:4049-57.
PubMed Abstract  pdf

Barr, H., Hermann, A., Berger, J., Tsai, H.H., Adie, K., Prokhortchouk, A., Hendrich, B., Bird, A.(2007). Mbd2 contributes to DNA methylation-directed repression of the Xist gene. Mol Cell Biol. 27(10):3750-7.
PubMed Abstract  pdf

Guy, J., Selfridge, J., Gan, J., Cobb, S. and Bird, A. (2007). Reversal of Neurological Defects in a Mouse Model of Rett Syndrome. Science. 315, 1143-7.
PubMed Abstract  pdf

[2006]

Jorgensen, H. F., Adie, K., Chaubert, P., and Bird, A. P. (2006). Engineering a high-affinity methyl-CpG-binding protein. Nucleic Acids Res 34, e96.
PubMed Abstract  pdf

Hu K, Nan X, Bird A, Wang W. (2006). Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nat Genet. 38(9):962-4;
PubMed Abstract  pdf

Klose, R. J., and Bird, A. P. (2006). Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 31, 89-97.
PubMed Abstract  pdf

Kriaucionis, S., Paterson, A., Curtis, J., Guy, J., Macleod, N., and Bird, A. (2006). Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol Cell Biol 26, 5033-5042.
PubMed Abstract  pdf

Prokhortchouk, A., Sansom, O., Selfridge, J., Caballero, I. M., Salozhin, S., Aithozhina, D., Cerchietti, L., Meng, F. G., Augenlicht, L. H., Mariadason, J. M., et al. (2006). Kaiso-deficient mice show resistance to intestinal cancer. Mol Cell Biol 26, 199-208.
PubMed Abstract  pdf

[2005]

Hutchins, A.S., Artis, D., Hendrich, B.D., Bird, A.P., Scott, P. and Reiner, S.L. (2005). Cutting edge: a critical role for gene silencing in preventing excessive type 1 immunity. J. Immunol. 175: 5606-5610.
PubMed Abstract  pdf

Suzuki, M.M., Nishikawa, T. and Bird, A. (2005) . Genomic changes reveal unexpected divergence within Ciona intestinalis. J. Mol. Evol. 61: 627-635.
PubMed Abstract  pdf

Klose, RJ., Sarraf, SA., Schmiedeberg, L,, McDermott, SM., Stancheva, I and Bird AP. [2005] DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. Mol Cell. 19(: 667-78.
PubMed Abstract  pdf

Nuber, UA,. Kriaucionis, S., Roloff, TC., Guy, J., Selfridge, J., Steinhoff, C., Schulz, R., Lipkowitz, B., Ropers, HH., Holmes, MC and Bird. A. [2005] Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet. 2005 14: 2247-56
PubMed Abstract  pdf

Sansom, O.J., Bishop, S.M., Bird, A. and Clarke, A.R. (2005). MBD2 deficiency does not accelerate p53 mediated
lymphomagenesis.
 Oncogene 24, 2430-2432.
PubMed Abstract  pdf

Bisoni, L., Batlle-Morera, L., Bird, A.P., Suzuki, M. and McQueen, H.A. (2005). Female-specific hyperacetylation of histone H4 in the chicken Z chromosome. Chromosome Res 13, 205-214.
PubMed Abstract  pdf